Preheat the oven to 425°F (220°C) and line a baking sheet with parchment paper.
In a mixing bowl, combine shredded chicken, cream cheese, cheddar cheese, salsa, garlic powder, onion powder, cumin, salt, and pepper. Stir until well-mixed.
Spoon about 2-3 tablespoons of filling onto each tortilla, spreading it evenly in a line. Roll up tightly and place seam-side down on the baking sheet.
Lightly brush each taquito with cooking spray or olive oil. Bake for 15-18 minutes or until golden brown and crispy.
Serve warm with sour cream, guacamole, or salsa on the side.