Preheat the oven to 400°F (200°C). Cut the spaghetti squash in half lengthwise and scoop out the seeds.

Place the squash halves cut-side down on a baking sheet and bake for 30-40 minutes until tender.

In a saucepan over medium heat, combine heavy cream, garlic powder, onion powder, salt, and black pepper. Bring to a simmer.

Remove from heat and stir in cheddar and mozzarella cheese until melted and smooth.

Once the squash is cool enough to handle, use a fork to scrape out the strands into a mixing bowl.

Add the cheese sauce to the spaghetti squash and mix well.

Transfer the mixture to a baking dish.

In a small bowl, combine bread crumbs, Parmesan cheese, and melted butter. Sprinkle over the top of the squash mixture.

Bake in the oven for an additional 15-20 minutes until the top is golden brown.