Preheat your oven to 375°F (190°C) and line a baking sheet with parchment paper.
In a skillet over medium heat, brown the ground beef until fully cooked, breaking it apart with a spatula. Drain excess fat.
Season the beef with salt, black pepper, garlic powder, onion powder, and Worcestershire sauce. Stir in the shredded cheddar cheese until melted and well combined.
Roll out each biscuit until approximately 1/4 inch thick. Place about 2 tablespoons of the cheesy beef mixture in the center of each biscuit.
Carefully fold the edges of the dough around the filling and pinch to seal, forming a ball. Place seam-side down on the prepared baking sheet.
In a small bowl, combine melted butter and minced garlic. Brush the tops of each cheeseburger bomb with this garlic butter mixture.
Sprinkle grated Parmesan cheese evenly over each bomb.
Bake in the preheated oven for 12-15 minutes or until golden brown and cooked through.
Garnish with fresh parsley before serving.